National Toxicology Program

National Toxicology Program

Testing Status of Tetrachlorvinphos - 10929-H


CASRN: 961-11-5

Formula: C10-H9-Cl4-O4-P

Synonyms/Common Names

  • Phosphoric acid, 2-chloro-1-(2,4,5-trichlorophenyl)ethenyl dimethyl ester (9CI)

Known Uses

Pesticide, cholinesterase inhibitor (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00168)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00168)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 500, 8000 (AVG), M: 0, 2000, 32000 (AVG) PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00168)  Report Complete 
    • TR-033 (NIH Number: 78-833)  (Peer Review Approval 11/28/1977A )
      Bioassay of Tetrachlorvinphos for Possible Carcinogenicity (CASRN 961-11-5)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0, 4250, 8500 (AVG), M: 0, 800, 1600 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (724074)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (220423)  Completed 
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.