National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10936-e

Testing Status of Prednisone - 10936-E

 

CASRN: 53-03-2

Formula: C21-H26-O5

Synonyms/Common Names

  • Deltacortisone
  • 17,21-Dihydroxy-pregna-1,4-diene-3,11,20-trione (9CI)

Known Uses

Oral glucocorticoid for antiinflammatory or immunosuppressant effects indicated treatment of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, respiratory, hematologic, gastrointestinal, edematous, and neoplastic (PDR, 1979)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C04897)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss
  • 13-Week (Intraperitoneal Injection)  (C04897)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C04897)  Report Complete 
    •   (Peer Review Approval NA) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
    • Rats: Sprague Dawley; Mice: Swiss
    • Dose: R: 0, 11, 22, 45, M: 0, 6, 12, 25 MG/KG/25 PER GROUP.

Genetic Toxicology

  • Salmonella  (217172)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
  • Salmonella  (240172)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
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