National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10938-l

Testing Status of Phenoxybenzamine hydrochloride - 10938-L

 

CASRN: 63-92-3

Formula: C18-H22-Cl-N-O.Cl-H

Synonyms/Common Names

  • N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine hydrochloride (CI)

Known Uses

Antihypertensive agent

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C01661)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
  • 13-Week (Intraperitoneal Injection)  (C01661)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C01661)  Report Complete 
    • TR-072 (NIH Number: 78-1322)  (Peer Review Approval 03/07/1978A )
      Bioassay of Phenoxybenzamine Hydrochloride for Possible Carcinogenicity (CASRN 63-92-3)
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (926929)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (695265)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive 
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