National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10940-n

Testing Status of Phenesterin - 10940-N

 

CASRN: 3546-10-9

Formula: C39-H59-Cl2-N-O2

Synonyms/Common Names

  • Cholest-5-en-3-ol (3beta)-, 4-(bis(2-chloroethyl)amino)benzeneacetate

Known Uses

Anticancer drug

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C01558)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
  • 13-Week (Gavage)  (C01558)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C01558)  Report Complete 
    • TR-060 (NIH Number: 78-1310)  (Peer Review Approval 03/06/1978A )
      Bioassay of Phenesterin for Possible Carcinogenicity (CASRN 3546-10-9)
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 

Genetic Toxicology

  • Drosophila  (422979)  Completed 
    • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (012521)  Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    • Mice
    •  Negative 
  • Salmonella  (461280)  Completed 
    •  Negative 
  • Salmonella  (612071)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.