Testing Status of Parathion 10942-W

 

CASRN: 56-38-2

Formula: C10-H14-N-O5-P-S

Synonyms/Common Names

  • Phosphorothioic acid, O,O-diethyl O-(4-nitrophenyl)ester (9CI)

Known Uses

Pesticide. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00226)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00226)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 5, 320, M: 0, 160, 1280 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00226)  Report Complete 
    • TR-070 (NIH Number: 79-1320)  (Peer Review Approval 08/31/1978A )
      Bioassay of Parathion for Possible Carcinogenicity (CASRN 56-38-2)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Equivocal 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: MR: 0, 32, 63 (AVG), FR: 0, 23, 45 (AVG), M: 0, 80, 160 PPM/50 PER GROUP.

Special Studies

  • C. elegans  (S0904)  Completed 
    • C. elegans
    • Dose: repro: (0, .0025, .004, .0063, .01, .016, .025, .04, .063, .1, .16, .25) mM 08/30/06 GROWTH: (0, .01, .016, .025, .04, .063, .1, .16, .25, .40, .63, 1) mM 07/30/07Feed: (0, .0025, .004, .0063, .01, .016, .025, .04, .063, .1, .16, .25) mM 04/20/07.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (580599)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (512404)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Weakly Positive 
  • Salmonella  (533981)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative