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Testing Status of o-Nitrotoluene 10946-L

 

CASRN: 88-72-2

Formula: C7-H7-N-O2

Synonyms/Common Names

  • 1-Methyl-2-nitrobenzene (9CI)
  • 2-Nitrotoluene

Known Uses

Intermediate for toluidines, organic synthesis of pesticides, pharmaceuticals, manufacture of dyes, rubber chemicals. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 1 week (Dosed-Feed)  (C62340C)  Completed 
    • Rats: F344/N
  • 2 weeks (Dosed-Feed)  (C62340)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 26 weeks (Dosed-Feed)  (C62340C)  Completed 
    • Rats: F344/N
    • Dose: MALE R: 0, 0 ALTERED MICROFLORA 20/GRP; 5000 PPM 60/GRP; 5000 PPM ALTERED MICROFLORA 40/GRP.
  • 13 weeks (Dosed-Feed)  (C62340)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 625, 1250, 2500, 5000, 10000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C62340D)  Completed 
    • TR-504 (NIH Number: 02-4438)  (Peer Review Approval 05/03/2001A )
      Toxicology and Carcinogenesis Studies of o-Nitrotoluene (CASRN 88-72-2) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: MR: 0, 625, 1250, 2000, OR 5000 PPM FR: 0, 625, 1250, OR 2000 PPM M: 0, 1250, 2500, OR 5000 PPM; 60/SEX/DOSE.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0206)  Completed 
    • Male Rats: F344/N
    • Dose: 260 MG/KG.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (573604)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A25222)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
    • Female Negative 
  • Micronucleus  (A29734)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A80173)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Salmonella  (192331)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
  • Salmonella  (692737)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative