Testing Status of Acetone 10947-R

 

CASRN: 67-64-1

Formula: C3-H6-O

Synonyms/Common Names

  • 2-Propanone

Known Uses

Chemical intermediate; solvent; explosives. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Water)  (C00022)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Water)  (C00022)  Report Complete 
    • TOX-03 (NIH Number: 91-3122)
      Toxicity Studies of Acetone in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) (CASRN 67-64-1)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: MM: 0, .125, .25, .5, 1.0, 2.0 % R&FM: 0, .25, .5, 1.0, 2.0, 5.0%.

Genetic Toxicology

  • Comet Assay (Gavage & Dosed-Water)  (G10947)  On Test 
    • Rats: Harlan Sprague-Dawley
  • In Vitro Cytogenetics (CA/SCE)  (197425)  Completed 
    • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A71579)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (230717)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 

Organ Systems Toxicity

  • 8 to 15 GD (copulatory plug=0 GD) Short-Term in vivo Repro. Tox. (Gavage)  (T0017)  Completed 
    • Female Mice: Swiss
  • 6 to 19 GD Conventional Teratology (Inhalation)  (TER87036)  Completed 
    • Citation: Inhalation Developmental Toxicology Studies: Teratology Study of Acetone in Mice and Rats (November 1988)
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: R: 0, 440, 2200, 11000* PPM.
  • 6 to 17 GD Conventional Teratology (Inhalation)  (TER87140)  Completed 
    • Citation: Inhalation Developmental Toxicology Studies: Teratology Study of Acetone in Mice and Rats (November 1988)
    • Female Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 0, 440, 2200, 6600 PPM.