National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10957-y

Testing Status of Ozone - 10957-Y

 

CASRN: 10028-15-6

Formula: O3

Synonyms/Common Names

  • Triatomic oxygen

Known Uses

Pollution control, waste treatment, chemical synthesis, sterilization where residuals of other chemicals would be objectionable, odor control, bleaching waxes, clay, textiles, paper pulp, oils, control of algae, mold, and bacteria. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 4 weeks (Inhalation)  (C88034)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.5, OR 1.0 PPM (5/SEX/SPECIES/GROUP).

Long-Term Carcinogenicity

  • Lifetime (Inhalation)  (C88034B)  Report Complete 
    • TR-440 (NIH Number: 95-3371)  (Peer Review Approval 11/16/1993A )
      Toxicology and Carcinogenesis Studies of Ozone (CASRN 10028-15-6) and Ozone/NNK (CASRN 10028-15-6/64091-91-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice Some Evidence 
    • Dose: R&M: 0, 0.5, OR 1.0 PPM (50/SEX/SPECIES/GROUP).
  • 2 years (Inhalation)  (C88034)  Report Complete 
    • TR-440 (NIH Number: 95-3371)  (Peer Review Approval 11/16/1993A )
      Toxicology and Carcinogenesis Studies of Ozone (CASRN 10028-15-6) and Ozone/NNK (CASRN 10028-15-6/64091-91-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice Some Evidence 
    • Dose: R&M: 0, 0.12, 0.5, OR 1.0 PPM (50/SEX/SPECIES/GROUP).

Genetic Toxicology

  • Salmonella  (A31529)  Completed 
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.