National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10962-l

Testing Status of 1,2-Dichloroethane - 10962-L

 

CASRN: 107-06-2

Formula: C2-H4-Cl2

Synonyms/Common Names

  • Ethylene dichloride
  • Ethylene dichloride (EDC)

Known Uses

Production of vinyl chloride and other chlorinated chemicals; lead scavenger; fumigant; solvent for pharmaceutical products, upholstery and carpet cleaner, rubber goods (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 14-Day (Gavage)  (C00511A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Gavage)  (C00511A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 40, 251, M: 0, 159, 1000 MG/KG/5 PER GROUP.
  • 13 weeks (Gavage)  (C00511B)  Report Complete 
    • TOX-04 (NIH Number: 91-3123)
      Toxicity Studies of 1,2-Dichloroethane (Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-Mendel Rats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (CASRN 107-06-2)
    • Rats: F344/N
    • Dose: MR: 0, 30, 60, 120, 240, 480; FR: 0, 20, 40, 75, 150, 300 MG/KG/10 PER GROUP.
  • 13 weeks (Dosed-Water)  (C00511C)  Report Complete 
    • TOX-04 (NIH Number: 91-3123)
      Toxicity Studies of 1,2-Dichloroethane (Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-Mendel Rats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (CASRN 107-06-2)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 500, 1000, 2000, 4000, 8000 PPM (10 PER GROUP).
  • 13 weeks (Dosed-Water)  (C00511D)  Report Complete 
    • TOX-04 (NIH Number: 91-3123)
      Toxicity Studies of 1,2-Dichloroethane (Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-Mendel Rats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (CASRN 107-06-2)
    • Rats: Osborne Mendel; Rats: Sprague Dawley
    • Dose: R: 0, 500, 1000, 2000, 4000, 8000 PPM (10 PER GROUP).

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C00511A)  Report Complete 
    • TR-055 (NIH Number: 78-1361)  (Peer Review Approval 03/06/1978A )
      Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity (CASRN 107-06-2)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0, 47, 95 (AVG), MM: 0, 97, 195 (AVG), FM: 0, 149, 299 (AVG) MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (756073)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (A32670)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (446462)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 
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