Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of 1,2-Dichloroethane 10962-L

 

CASRN: 107-06-2

Formula: C2-H4-Cl2

Synonyms/Common Names

  • Ethylene dichloride
  • Ethylene dichloride (EDC)

Short-Term Toxicity

  • 14-Day (Gavage)  (C00511A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Gavage)  (C00511A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 40, 251, M: 0, 159, 1000 MG/KG/5 PER GROUP.
  • 13 weeks (Gavage)  (C00511B)  Completed 
    • TOX-04 (NIH Number: 91-3123)
      Toxicity Studies of 1,2-Dichloroethane (Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-Mendel Rats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (CASRN 107-06-2)
    • Rats: F344/N
    • Dose: MR: 0, 30, 60, 120, 240, 480; FR: 0, 20, 40, 75, 150, 300 MG/KG/10 PER GROUP.
  • 13 weeks (Dosed-Water)  (C00511C)  Completed 
    • TOX-04 (NIH Number: 91-3123)
      Toxicity Studies of 1,2-Dichloroethane (Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-Mendel Rats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (CASRN 107-06-2)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 500, 1000, 2000, 4000, 8000 PPM (10 PER GROUP).
  • 13 weeks (Dosed-Water)  (C00511D)  Completed 
    • TOX-04 (NIH Number: 91-3123)
      Toxicity Studies of 1,2-Dichloroethane (Ethylene Dichloride) in F344/N Rats, Sprague Dawley Rats, Osborne-Mendel Rats, and B6C3F1 Mice (Drinking Water and Gavage Studies) (CASRN 107-06-2)
    • Rats: Osborne Mendel; Rats: Sprague Dawley
    • Dose: R: 0, 500, 1000, 2000, 4000, 8000 PPM (10 PER GROUP).

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C00511A)  Completed 
    • TR-055 (NIH Number: 78-1361)  (Peer Review Approval 03/06/1978A )
      Bioassay of 1,2-Dichloroethane for Possible Carcinogenicity (CASRN 107-06-2)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0, 47, 95 (AVG), MM: 0, 97, 195 (AVG), FM: 0, 149, 299 (AVG) MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (756073)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (A32670)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (446462)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive