National Toxicology Program

National Toxicology Program

Testing Status of tert-Butylphenyl Diphenyl Phosphate - 10978-T


CASRN: 56803-37-3

Formula: C22-H23-O4-P

Synonyms/Common Names

  • BPDP
  • Flame Retardant 1
  • Phosphoric acid, (1,1-dimethylethyl)phenyl diphenyl ester
  • TBDP

Known Uses

Used as plasticizer in nail polish; flame retardant plasticizer for polyvinyl chloride.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Planned Carcinogenicity/Toxicity

  • Perinatal dose range finding Selected (C20715)  
    • Rats: Harlan Sprague-Dawley
  • 90 days Selected (C20715)  
    • Mice: B6C3F1

Short-Term Toxicity

  • 5 days (Gavage)  (C10978)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 0.169, 0.338, 0.675, 1.35, 2.70 mMol/kg; 5/species/dose.

Special Studies

  • C. elegans  (W10978)  Completed 
    • C. elegans

Genetic Toxicology

  • Salmonella  (740508)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • Immunotoxicity  (I10978)  Assigned 
    • Developmental Immunotoxicity
    • Male and Female Rats: Harlan Sprague-Dawley


  • Microarray Analysis (Gavage) Selected (T10978)  
    • Rats: Harlan Sprague-Dawley
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.