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Testing Status of tert-Butylphenyl Diphenyl Phosphate 10978-T

 

CASRN: 56803-37-3

Formula: C22-H23-O4-P

Synonyms/Common Names

  • BPDP
  • Flame Retardant 1
  • Phosphoric acid, (1,1-dimethylethyl)phenyl diphenyl ester
  • TBDP

Known Uses

Used as plasticizer in nail polish; flame retardant plasticizer for polyvinyl chloride.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 5 days (Gavage)  (C10978)  Completed 
    • Citation: Behl M, Hsieh JH, Shafer TJ, Mundy WR, Rice JR, Boyd WA, Freedman JH, Hunter ES, III, Jarema KA, Padilla S, Tice RR. Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. Neurotoxicol Teratol. 2015 Nov-Dec;52:181-193
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 0.169, 0.338, 0.675, 1.35, 2.70 mMol/kg; 5/species/dose.

Special Studies

  • C. elegans  (W10978)  Completed 
    • Citation: Behl M, Rice JR, Smith MV, Co CA, Bridge M, Hsieh JH, Freedman JH, Boyd WA. Comparative toxicity of organophosphate flame retardants and polybrominated diphenyl ethers to c. Elegans. Toxicol Sci. 2016 Aug;154(2):241-252Pubmed Abstract
    • C. elegans
    • Dose: Growth: 0, 1, 1.6, 2.5, 4.0, 6.3, 10, 16, 25, 40, 63, 100uMRepro: 0, 1, 1.6, 2.5, 4.0, 6.3, 10, 16, 25, 40, 63, 100uMFeeding: 0, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uM.

Genetic Toxicology

  • Salmonella  (740508)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • Immunotoxicity Selected (I10978)  
    • Developmental Immunotoxicity
    • Male and Female Rats: Harlan Sprague-Dawley

Toxicogenomics

  • Microarray Analysis (Gavage)  (T10978)  Completed 
    • Rats: Harlan Sprague-Dawley