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Testing Status of Dibromoacetonitrile 10985-P

 

CASRN: 3252-43-5

Formula: C2-H-Br2-N

Synonyms/Common Names

  • Dibromoacetonitrile

Known Uses

Formed as a result of the reaction of chlorine oxidizing compounds (e.g., chlorine gas, hypochlorous acid, and hypochlorite) with natural organic matter, particularly nitrogen-containing organic compounds, in water containing bromine; it is also a by-product of ozone disinfection.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0820)  Completed 
    • Citation: [14C] Dibromoacetonitrile: Comparative metabolism and excretion in rats and mice.
    • Male Rats: F344/N; Male Mice: B6C3F1; Male Rats: F344/N; Male Mice: B6C3F1
    • Dose: 0.2, 2 and 20 mg/kg.

Genetic Toxicology

  • Drosophila  (369991)  Completed 
    • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Micronucleus  (A00107)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (298559)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Weakly Positive 
  • Salmonella  (450116)  Completed 
    •  Weakly Positive 
  • Salmonella  (573952)  Completed 
    •  Equivocal 
  • Salmonella  (877154)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Weakly Positive 
  • Salmonella  (A44565)  Completed 
    •  Positive 

Organ Systems Toxicity

  • 35 days Repro/Dev Gen Tox (28-Day) (Dosed-Water)  (RDGT94014)  Completed 
    • Citation: Reproductive Toxicity of Dibromoacetonitrile (CAS #3252-43-5) Administered in Diet to SD Rats
    • Male and Female Rats: Sprague Dawley
    • Dose: 0, 15, 50, OR 150 PPM.