National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10987-x

Testing Status of Dibutyl Phthalate - 10987-X

 

CASRN: 84-74-2

Related: PEROXISOME PROJECT (DIBUTYL PHTHALATE)

Formula: C16-H22-O4

Synonyms/Common Names

  • 1,2-Benzenedicarboxylic acid, dibutyl ester
  • DIBP

Known Uses

Insect repellant for impregnation of clothing. Plasticizer. Solvent. Textile lubricating agent. A wide-spectrum biocide most frequently used as a fungicide to combat the formation of slime in paper and pulp mill operations. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • perinatal (Dosed-Feed)  (C62022)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C62022B)  Report Complete 
    • TOX-30 (NIH Number: 95-3353)  (Tox Peer Review 08/00/1994A )
      Toxicity Studies of Dibutyl Phthalate (CASRN 84-74-2) Administered in Feed to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 2500, 5000, 10000, 20000, OR 40000 PPM R: 0, 1250, 2500, 5000, 10000, 20000 PPM (10/S/S).
  • post-wean (Dosed-Feed)  (C62022)  Report Complete 
    • TOX-30 (NIH Number: 95-3353)  (Tox Peer Review 08/00/1994A )
      Toxicity Studies of Dibutyl Phthalate (CASRN 84-74-2) Administered in Feed to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N
    • Dose: IN UTERO WITH F344 RATS; SEE C62022B.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C10987)  Histopath in progress 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: R: 0, 300, 1000, 3000, or 10,000 ppm; M: 0, 1000, 3000, or 10,000 ppm; 50/sex/species/group.

Special Studies

  • Absorption Disposition Metabolism Elimination (Topical Application)  (S0045)  Completed 
    • Rats
  • Toxicokinetic Study (Gavage; Intravenous)  (S0545)  Completed 
    • Male Rats: Sprague Dawley; Male Mice: B6C3F1; Male Hamsters: Syrian Golden; Male Rats: Sprague Dawley; Male Mice: B6C3F1; Male Hamsters: Syrian Golden
  • Toxicokinetic Study (Dosed-Feed)  (S0580)  Completed 
    • Male Rats: Sprague Dawley; Male Mice: B6C3F1; Male Hamsters: Syrian Golden

Genetic Toxicology

  • Mouse Lymphoma  (800748)  Completed 
    • Mice
    •  Positive 
  • Micronucleus  (A17278)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (077089)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 

Organ Systems Toxicity

  • Continuous Breeding (Legacy) (Gavage)  (RACB20107A)  Completed 
    • Male and Female Rats: SD & Wistar
  • continuous exposure, 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)  (RACB83084)  Completed 
    • Citation: Final Report - Di (n-butyl) phthalate: Reproduction and Fertility Assessment In CD-1 Mice When Administered in the Feed
    • Male and Female Mice: Swiss
    • Dose: N/A; 0..03,.3,1.0%; N/A; N/A.
  • greater than 120 days Continuous Breeding (Legacy) (Dosed-Feed)  (RACB89012)  Completed 
    • Citation: Final Report on the Reproductive Toxicity of Di-N-Butyl Phthalate in Sprague-Dawley Rats
    • Male and Female Rats: Sprague Dawley
    • Dose: 0.1,0.5,1.0,1.5,2.0%; 0,.1,.5,1.0%; 0,1%; 0,.1,.5,1.0%.
  • Continuous Breeding (Legacy) (Dosed-Feed)  (RACB97003)  Completed 
    • Citation: Dibutyl Phthalate: Multigenerational Reproductive Assessment by Continuous Breeding When Administered to Sprague-Dawley Rats in the Diet (2 volumes)
    • Male and Female Rats: Sprague Dawley
  • 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0035A)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 2500 MG/KG BODY WT..
  • Utero-Lactational (Gavage)  (R10987B)  Completed 
    • Rats: F344/N
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.