Testing Status of Diethylamine 10992-K

 

CASRN: 109-89-7

Formula: C4-H11-N

Synonyms/Common Names

  • Diethamine
  • Ethanamine, N-ethyl-
  • N-Ethylethanamine

Known Uses

Used in the production of the corrosion inhibitor n,n-diethylethanolamine, and in the production of some pesticides and insect repellents, pharmaceuticals and rubber processing chemicals (Executive Summary). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C99017)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 31, 62.5, 125, 250, OR 500 PPM; 5/SEX/SPECIES/DOSE.
  • 13 weeks (Inhalation)  (C99017)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 8, 16, 32, 62, OR 125 PPM; R: 20/SEX/DOSE; M: 10/SEX/DOSE.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C99017)  Report Complete 
    • TR-566 (NIH Number: 10-5908)  (Peer Review Approval 11/19/2009A )
      Toxicology and Carcinogenesis Studies of Diethylamine (CASRN 109-89-7) in F344/N Rats and B6C3F1 Mice (Inhalation studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 31, 62.5, OR 125 PPM M: 0, 16, 31, OR 62.5 PPM; 50/SEX/SPECIES/DOSE.

Genetic Toxicology

  • Micronucleus  (A56444)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (752053)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
  • Salmonella  (A72050)  Completed 
    •  Negative