National Toxicology Program

National Toxicology Program

Testing Status of Diethylene glycol - 10993-P


CASRN: 111-46-6

Formula: C4-H10-O3

Synonyms/Common Names

  • 2,2'-Oxydiethanol

Known Uses

In antifreeze solution, textile lubricating agent, vat dye solvent, cork composites, glues, gelatin, pastes, photographic developer(Merck 1989). Tobacco humectant, casein, synthetic sponges, paper products, adhesives, cosmetics, lacquers (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination (Dosed-Water; Gavage; Intravenous)  (S0219)  Completed 
    • Citation: Mathews JM, Parker MK, Matthews HB. Metabolism and disposition of diethylene glycol in rat and dog. Drug Metab Dispos. 1991 Nov-Dec;19(6):1066-70.Pubmed Abstract
    • Male Rats: F344/N; Female Dog: Beagles; Male Rats: F344/N

Genetic Toxicology

  • Salmonella  (248390)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • continuous exposure, 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB83086)  Completed 
    • Citation: Final Report - Diethylene Glycol: Reproduction and Fertility Assessment in CD-1 Mice When Administered In the Drinking Water
    • Male and Female Mice: Swiss
    • Dose: N/A; 0,.35,1.75,3.5%; N/A; N/A.
  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0075A)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 11,180 MG(10ML UNDILUTED)/KG BODY WEIGHT.
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER89001)  Completed 
    • Citation: Final Report on the Developmental Toxicity of Diethylene Glycol in CD-1 Swiss Mice
    • Female Mice: Swiss CD-1
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 0, 1250, 5000, 10000 MG/KG/DAY.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.