National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10996-c

Testing Status of Di(n-hexyl)phthalate - 10996-C

 

CASRN: 84-75-3

Formula: C20-H30-O4

Synonyms/Common Names

  • 1,2-Benzenedicarboxylic acid, dihexyl ester

Known Uses

Plasticizer for cellulose & vinyl plastics. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination (Dosed-Water)  (S0378)  Completed 
    • Male Rats: F344/N

Genetic Toxicology

  • Salmonella  (177536)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 
  • Salmonella  (699952)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 

Organ Systems Toxicity

  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)  (RACB84093)  Completed 
    • Citation: Final Report - Di-N-Hexyl Phthalate: Reproduction and Fertility Assessment In CD-1 Mice When Administered In the Feed
    • Male and Female Mice: Swiss
    • Dose: N/A; 0,0.3,0.6,1.2%; 0,1.2%; 0,.3,.6,1.2%.
  • 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0036A)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 9900 (UNDILUTED) MG/KG BODY WT.
  • Utero-Lactational (Gavage)  (R10996)  Completed 
    • Mice: Swiss
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.