National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-10997-f

Testing Status of Diisobutyl Phthalate - 10997-F

 

CASRN: 84-69-5

Formula: C16-H22-O4

Synonyms/Common Names

  • 1,2-Benzenedicarboxylic acid, bis(2-methylpropyl) ester

Known Uses

Plasticizer. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Salmonella  (675507)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 

Organ Systems Toxicity

  • Continuous Continuous Breeding (Dosed-Feed)  (R10997)  Completed 
    • Male and Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 1000, 5000, or 10000 ppm.
  • 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0034)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 4000 MG/KG BODY WEIGHT.
  • Utero-Lactational (Gavage)  (R10997B)  Completed 
    • Rats: F344/N
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