National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11001-y

Testing Status of Dimethyl phthalate - 11001-Y

 

CASRN: 131-11-3

Formula: C10-H10-O4

Synonyms/Common Names

  • 1,2-Benzenedicarboxylic acid, dimethyl ester

Known Uses

Insect repellant, plasticizer, solvent, and dye carrier. Used in cosmetics and solid rocket propellant. Solvent and plasticizer for cellulose acetate and cellulose acetate-butyrate compositions. Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination (Topical Application)  (S0043)  Completed 
    • Male Rats: F344/N

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (970550)  Completed 
    • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A47213)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A65972)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Salmonella  (856145)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 

Organ Systems Toxicity

  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0098A)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 3500 MG/KG BODY WT..
  • 6 to 13 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0098B)  Completed 
    • Female Mice: Swiss
    • Dose: 5000 MG/KG/DY.
  • 6 to 15 GD Conventional Teratology (Dosed-Feed)  (TER88066)  Completed 
    • Citation: Developmental Toxicity Evaluation of Dimethyl Phthalate Administered to CD Rats on Gestational Days 9 through 15
    • Female Rats: Sprague Dawley
    • Rats Maternal Negative 
    • Rats Fetal Negative 
    • Dose: 0.25, 1.0, 5.0%.
  • Utero-Lactational (Dosed-Water)  (R11001)  Completed 
    • Mice: B6C3F1
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.