National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11002-d

Testing Status of Dioctyl phthalate - 11002-D

 

CASRN: 117-84-0

Formula: C24-H38-O4

Synonyms/Common Names

  • 1,2-Benzenedicarbonic acid, dioctyl ester

Known Uses

Dye carrier; used as a plasticizer in plastics & rubber materials, cellulose ester resins, polystyrene resins, vinyl resins. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Toxicokinetic Study (Topical Application)  (S0047)  Completed 
    • Male Rats: F344/N

Genetic Toxicology

  • Salmonella  (436106)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 

Organ Systems Toxicity

  • continuous exposure, 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)  (RACB85047)  Completed 
    • Citation: Final Report - Di-N-Octylphthalate: Reproduction and Fertility Assessment in CD-1 Mice When Administered in Feed
    • Male and Female Mice: Swiss
    • Dose: N/A; 1.25, 2.5 %; N/A; N/A.
  • 7 to 14 GD (PLUG = 1 gestation day) Short-Term in vivo Repro. Tox. (Gavage)  (T0087A)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 9780 MG (10 ML UNDILUTED)/KG/DAY.
  • Utero-Lactational (Dosed-Water)  (R11002)  Completed 
    • Rats: F344/N
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