National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11010-d

Testing Status of 1,2-Epoxy-3,3,3-trichloropropane - 11010-D

 

CASRN: 3083-23-6

Formula: C3-H3-Cl3-O

Synonyms/Common Names

  • (Trichloromethyl)oxirane

Known Uses

Fireproofing agent, polymer intermediate

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (800706)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • In Vitro Cytogenetics (CA/SCE)  (919832)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (261200)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Salmonella  (432029)  Completed 
    • Citation: Canter, D.A., Zeiger, E., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Comparative mutagenicity of aliphatic epoxides in Salmonella Mutation Res. Vol. 172 (1986) 105-138
    •  Positive 
  • Salmonella  (868758)  Completed 
    • Citation: Canter, D.A., Zeiger, E., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Comparative mutagenicity of aliphatic epoxides in Salmonella Mutation Res. Vol. 172 (1986) 105-138
    •  Positive 
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