Testing Status of Methyl isocyanate 11019-N

 

CASRN: 624-83-9

Formula: C2-H3-N-O

Synonyms/Common Names

  • Isocyanatomethane (9CI)

Known Uses

Chemical intermediate for insecticides, herbicides. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C62146)  Completed 
    • Citation: Bucher JR, Uraih LC, Hildebrandt PK, Sauer RM and Seely JC. Carcinogenicity and Pulmonary Pathology Associated with a Single 2-Hour Inhalation Exposure of Laboratory Rodents to Methyl Isocyanate. J. Nat. Cancer Inst 81:1586-1587 (1989).
    • Rats: Not Available; Mice: Not Available

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (933693)  Completed 
    • Citation: Mason, J., Zeiger, E., Haworth, S., Ivett, J., and Valencia, R. Genotoxicity studies of methyl isocyanate in Salmonella, Drosophila, and cultured Chinese hamster ovary cells. Environ. Mutagen. Vol. 9 (1987) 19-28
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (736474)  Completed 
    • Citation: Mason, J., Zeiger, E., Haworth, S., Ivett, J., and Valencia, R. Genotoxicity studies of methyl isocyanate in Salmonella, Drosophila, and cultured Chinese hamster ovary cells. Environ. Mutagen. Vol. 9 (1987) 19-28
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (752783)  Completed 
    • Citation: Caspary, W., and Myhr, B. Mutagenicity of MIC and its reaction products to cultured mammalian cells. Mutation Res. Vol. 174 (1986) 285-293
    • Mice
    •  Positive 
  • Micronucleus  (A97304)  Completed 
    • Citation: Tice, R.R., Luke, C.A., and Shelby, M.D. Methyl isocyanate: An evalution of in vivo cytogenetic activity. Environ. Mutagen. Vol. 9 (1987) 37-58
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (290825)  Completed 
    • Citation: Mason, J.M., Zeiger, E., Haworth, S., Ivette, J., Valencia, R. Genotoxicity studies of methyl isocyanate in Salmonella, Drosphila, and cultured Chinese hamster ovary cells Environ. Mutagen. Vol. 9 (1987) 19-28
    •  Negative 
  • Salmonella  (327434)  Completed 
    • Citation: Mason, J.M., Zeiger, E., Haworth, S., Ivette, J., Valencia, R. Genotoxicity studies of methyl isocyanate in Salmonella, Drosphila, and cultured Chinese hamster ovary cells Environ. Mutagen. Vol. 9 (1987) 19-28
    •  Negative 
  • Sister Chromatid Exchanges  (A97304)  Completed 
    • Citation: Tice, R.R., Luke, C.A., and Shelby, M.D. Methyl isocyanate: An evalution of in vivo cytogenetic activity. Environ. Mutagen. Vol. 9 (1987) 37-58
    • Mice