National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11024-c

Testing Status of p-Nitrobenzoic acid - 11024-C

 

CASRN: 62-23-7

Related: P-NITROBENZOYL CHLORIDE (CAS 122-04-3)

Formula: C7-H5-N-O4

Synonyms/Common Names

  • Benzoic acid, 4-nitro- (9CI)

Known Uses

Produced in large volumes for organic synthesis and as an intermediate in the manufacture of pesticides, dyes, and industrial solvents.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C61778)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C61778)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, .062, 1.0, M: 0, .125, 2.0 %.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C61778B)  Report Complete 
    • TR-442 (NIH Number: 95-3358)  (Peer Review Approval 06/22/1993A )
      Toxicology and Carcinogenesis Studies of p-Nitrobenzoic Acid (CASRN 62-23-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Some Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: 0, 1250, 2500, OR 5000 PPM /60 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (195725)  Completed 
    • Citation: Zeiger, E., Shelby, M., Ivett J., and McFee, A. Mutagenicity testing of 5-(4-nitrophenyl)-2, 4-pentadien-1-al ("Spy Dust") and its metabolites in vitro and in vivo. Environ. Mutagen. Vol. 9 (1987) 269-280
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (A44876)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (699655)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Positive 

Organ Systems Toxicity

  • greater than 120 days Continuous Breeding (Legacy) (Dosed-Feed)  (RACB90065)  Completed 
    • Citation: Final Report on the Reproductive Toxicity of para-Nitrobenzoic Acid in CD-1 Swiss Mice
    • Male and Female Mice: Swiss
    • Dose: 0, .25, .50, 1.0, 2.0, 3.0; 0, .35, .75, 1.5%; 0, .75%; 0, .35, .75, 1.5%.
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