National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11035-n

Testing Status of 4,4-Thiobis(6-tert-butyl-m-cresol) - 11035-N

 

CASRN: 96-69-5

Formula: C22-H30-O2-S

Synonyms/Common Names

  • Santonox
  • TBBC
  • 4,4'-Thiobis(2-(1,1-dimethylethyl)-5-methylphenol (9CI)

Known Uses

Antioxidant for synthetic & natural rubber & latexes, stabilizer for polyethylene and polyolefin food packaging (HSDB 1990).

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C61610A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C61610A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,250,5000, M: 0,500,10000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C61610B)  Report Complete 
    • TR-435 (NIH Number: 95-3166)  (Peer Review Approval 06/22/1993A )
      Toxicology and Carcinogenesis Studies of 4,4'-Thiobis(6-t-butyl-m-cresol) (CASRN 96-69-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0,.05,.1,.25, M: 0,.025,.05,.1 %.

Special Studies

  • Absorption Disposition Metabolism Elimination (Intravenous)  (S0674)  Completed 
    • Citation: Borghoff SJ, Stefanski SA, Birnbaum LS. The effect of age on the glucuronidation and toxicity of 4,4'-thiobis(6-t-butyl-m-cresol). Toxicol Appl Pharmacol. 1988 Mar 15;92(3):453-66.Pubmed Abstract
    • Rats: F344/N
  • Absorption Disposition Metabolism Elimination (Topical Application)  (S0675)  Completed 
    • Citation: Birnbaum LS, Heaney SM. Dermal absorption of the antioxidant 4,4'-thiobis(6-tert-butyl-m-cresol) in Sencar mice and Fischer rats. Toxicol Lett. 1987 Jun;37(1):13-9.Pubmed Abstract
    • Rats: F344/N; Mice: Sencar
  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0677)  Completed 
    • Citation: Birnbaum LS, Eastin WC Jr, Johnson L, Matthews HB. Disposition of 4,4'-thiobis(6-t-butyl-m-cresol) in rats. Drug Metab Dispos. 1983 Nov-Dec;11(6):537-43.Pubmed Abstract
    • Rats: F344/N
  • Metabolism (Intravenous)  (S0676)  Completed 
    • Citation: Smith RW, Matthews HB, Parker CE, Hass JR. Identification of the major metabolite of 4,4'-thio-bis-(6-t-butyl-m-cresol). Biomed Mass Spectrom. 1985 May;12(5):208-14.Pubmed Abstract
    • Male Rats: F344/N

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (395386)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (755282)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • 14 days Immunotoxicity (Gavage)  (IMM95009)  Completed 
    • Female Mice: B6C3F1
    • Mice Female  NO OVERT TOXICITY
    • NO OVERT TOXICITY
    • Dose: 0, 10, 100, OR 200 MG/KG.
  • Neurotoxicology Assessment (Dosed-Feed)  (NTA94011)  Completed 
    • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
    • Male and Female Rats: F344/N
  • 8 to 15 GD (copulatory plug=0 GD) Short-Term in vivo Repro. Tox. (Gavage)  (T0043)  Completed 
    • Female Mice: Swiss
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