National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11037-w

Testing Status of Tri-m-cresyl phosphate - 11037-W

 

CASRN: 563-04-2

Formula: C21-H21-O4-P

Synonyms/Common Names

  • Phosphoric acid, tris(3-methylphenyl)ester (9CI)

Known Uses

Plasticizer in vinyl plastics manufacture; flame-retardant; solvent for nitrocellulose; in cellulosic molding compositions; nonflammable fluid in hydraulic systems; as lead scavenger in gasoline.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0051)  Completed 
    • Citation: Pharmacokinetics of three Tri-Cresyl Phosphates in the Fischer 344 male rats: Tri-Ortho-Cresyl Phosphate, Tri-Meta Cresyl Phosphate, Tri-Para-Cresyl Phosphate.
    • Male Rats: F344/N
    • Dose: gavage - 0.5, 2.0, 20.0 & 200 mg/kg Iv - 2.0 & 20.0 mk/kg.

Genetic Toxicology

  • Salmonella  (783054)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 
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