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Testing Status of Isopropylated Phenol Phosphate 11037

 

CASRN: 68937-41-7

Synonyms/Common Names

  • Durad 100
  • Flame Retardant 1
  • IPP
  • Isopropylated phenol phosphate (3:1)
  • Isopropylphenyl phosphate
  • Phenol isopropylated phosphate

Known Uses

Flame Retardants

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 5 days (Gavage)  (C10866B)  Completed 
    • Citation: Behl M, Hsieh JH, Shafer TJ, Mundy WR, Rice JR, Boyd WA, Freedman JH, Hunter ES, III, Jarema KA, Padilla S, Tice RR. Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. Neurotoxicol Teratol. 2015 Nov-Dec;52:181-193
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 0.169, 0.338, 0.675, 1.35, 2.70 mMol/kg; 5/species/dose.
  • 2 weeks (Dosed-Feed)  (C10866)  On Test 
    • Citation: Behl M, Hsieh JH, Shafer TJ, Mundy WR, Rice JR, Boyd WA, Freedman JH, Hunter ES, III, Jarema KA, Padilla S, Tice RR. Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. Neurotoxicol Teratol. 2015 Nov-Dec;52:181-193
    • Mice: B6C3F1/N
    • Dose: 0, 1875, 3750, 7500, 15000, or 30000 ppm; 5/sex.
  • 13 weeks (Dosed-Feed)  (C10866)  Assigned 
    • Citation: Behl M, Hsieh JH, Shafer TJ, Mundy WR, Rice JR, Boyd WA, Freedman JH, Hunter ES, III, Jarema KA, Padilla S, Tice RR. Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. Neurotoxicol Teratol. 2015 Nov-Dec;52:181-193
    • Mice: B6C3F1/N

Modified One-Generation

  • Dose Range Finding (Dosed-Feed)  (MOG10866)  On Test 
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 1000, 30000, 10000, 15000, or 30000 ppm.
  • F0 Generation (Dosed-Feed) Selected (MOG10866B)  
    • Rats: Harlan Sprague-Dawley
  • Neurotoxicology Assessment (Dosed-Feed) Selected (MOG10866B)  
    • Rats: Harlan Sprague-Dawley

Special Studies

  • C. elegans  (W10866)  Completed 
    • Citation: Behl M, Rice JR, Smith MV, Co CA, Bridge M, Hsieh JH, Freedman JH, Boyd WA. Comparative toxicity of organophosphate flame retardants and polybrominated diphenyl ethers to c. Elegans. Toxicol Sci. 2016 Aug;154(2):241-252Pubmed Abstract
    • C. elegans
    • Dose: Growth: 0, 1, 1.6, 2.5, 4.0, 6.3, 10, 16, 25, 40, 63, 100uMRepro: 0, 1, 1.6, 2.5, 4.0, 6.3, 10, 16, 25, 40, 63, 100uMFeeding: 0, 4, 6.3, 10, 16, 25, 40, 63, 100, 160, 250, 400uM.

Genetic Toxicology

  • Salmonella  (G10866)  Completed 
    •  Negative 

Toxicogenomics

  • Microarray Analysis (Gavage)  (T10866)  Completed 
    • Rats: Harlan Sprague-Dawley