National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11042-j

Testing Status of Triphenyl Phosphate - 11042-J

 

CASRN: 115-86-6

Formula: C18-H15-O4-P

Synonyms/Common Names

  • Flame Retardant 1
  • Phosphoric acid, triphenyl ester (9CI)
  • TPP

Known Uses

Noncombustible substitute for camphor; impregnating roofing paper; airplane "dope"; plasticizer in lacquers and varnishes; principally a flame retardant; impregnating upholstery.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Planned Carcinogenicity/Toxicity

  • 5 days (Gavage)  (C11042)   
    • Rats: Harlan Sprague-Dawley

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C20720)  On Test 
    • Mice: B6C3F1/N
    • Dose: 0, 1875, 3750, 7500, 15000, or 30000 ppm; 5/sex.

Modified One-Generation

  • Dose Range Finding (Dosed-Feed)  (MOG11042)  On Test 
    • Rats: Harlan Sprague-Dawley
  • F0 Generation Selected (MOG11042B)  
    • Rats: Harlan Sprague-Dawley
  • Neurotoxicology Assessment Selected (MOG11042B)  
    • Rats: Harlan Sprague-Dawley

Special Studies

  • C. elegans  (W11042)  Completed 
    • C. elegans

Genetic Toxicology

  • Salmonella  (888679)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • 8 days and 15 days Immunotoxicity (Topical Application & Intraductal Injection)  (IMM92060)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 0.1, 0.3, 1, 3, 10, OR 30% IRRITANCY ASSAY AND 0, 1.0, 3.0, 10, OR CHALLENGE 30% HYPERSENSITIVITY ASSAY.

Toxicogenomics

  • Microarray Analysis (Gavage) Selected (T11042)  
    • Rats: Harlan Sprague-Dawley
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