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Testing Status of Triphenyl Phosphate 11042-J

 

CASRN: 115-86-6

Formula: C18-H15-O4-P

Synonyms/Common Names

  • Flame Retardant 1
  • Phosphoric acid, triphenyl ester (9CI)
  • TPHP
  • TPP

Known Uses

Noncombustible substitute for camphor; impregnating roofing paper; airplane "dope"; plasticizer in lacquers and varnishes; principally a flame retardant; impregnating upholstery.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 5 days (Gavage)  (C11042)  Completed 
    • Citation: Behl M, Hsieh JH, Shafer TJ, Mundy WR, Rice JR, Boyd WA, Freedman JH, Hunter ES, III, Jarema KA, Padilla S, Tice RR. Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. Neurotoxicol Teratol. 2015 Nov-Dec;52:181-193
    • Rats: Harlan Sprague-Dawley
    • Dose:  0, 0.169, 0.338, 0.675, 1.35, 2.70 mMol/kg; 5/species/dose.
  • 2 weeks (Dosed-Feed)  (C20720)  Histopath in progress 
    • Citation: Behl M, Hsieh JH, Shafer TJ, Mundy WR, Rice JR, Boyd WA, Freedman JH, Hunter ES, III, Jarema KA, Padilla S, Tice RR. Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity. Neurotoxicol Teratol. 2015 Nov-Dec;52:181-193
    • Mice: B6C3F1/N
    • Dose: 0, 1875, 3750, 7500, 15000, or 30000 ppm; 5/sex.

Modified One-Generation

  • Dose Range Finding (Dosed-Feed)  (MOG11042)  On Test 
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 1000, 3000, 10000, 15000, or 30000 ppm.
  • F0 Generation Selected (MOG11042B)  
    • Rats: Harlan Sprague-Dawley
  • Neurotoxicology Assessment Selected (MOG11042B)  
    • Rats: Harlan Sprague-Dawley

Special Studies

  • C. elegans  (W11042)  Completed 
    • Citation: Behl M, Rice JR, Smith MV, Co CA, Bridge M, Hsieh JH, Freedman JH, Boyd WA. Comparative toxicity of organophosphate flame retardants and polybrominated diphenyl ethers to c. Elegans. Toxicol Sci. 2016 Aug;154(2):241-252Pubmed Abstract
    • C. elegans
    • Dose: Growth: 0, .04, 0.63, .1, .16, .25, .4, .63, 1, 1.6, 2.5, 4, 6.3, 10, 16, 25, 40uMRepro: 0, 0.1, 0.16, 0.25, 0.4, 0.63, 1, 1.6, 2.5, 4.0, 6.3, 10, 16, 25, 40, 63, 100uMFeeding: 0, 10, 16, 25, 40, 63, 100, 160, 250, 400, 630, 1000uM.

Genetic Toxicology

  • Salmonella  (888679)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • 8 days and 15 days Immunotoxicity (Topical Application & Intraductal Injection)  (IMM92060)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 0.1, 0.3, 1, 3, 10, OR 30% IRRITANCY ASSAY AND 0, 1.0, 3.0, 10, OR CHALLENGE 30% HYPERSENSITIVITY ASSAY.

Toxicogenomics

  • Microarray Analysis (Gavage) Selected (T11042)  
    • Rats: Harlan Sprague-Dawley