National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11042

Testing Status of Insertional Mutagenesis - Definitive Vector Study - 11042

 

CASRN: INSERTMUT3

Secondary:

  • EFSSINVECTOR - EFS SIN Vector
  • LTRVECTOR - LTR Vector
  • NTPMOCKVEC - NTP MOCK Vector
  • PSINVECTOR - P(-) SIN Vector
  • SINVECTOR - SIN vector
  • UORFLTRVECTOR - uORF LTR Vector

Known Uses

Insertional mutagenesis studies using various vector exposures (LTR; uORF LTR, SIN, EFS LTR, and P(-) SIN vectors.

Long-Term Carcinogenicity

  • 14 months (Intravenous)  (C10844B)  Assigned 
    • Mice: C57BL/6
    • Dose: Female mice: LTR and NTPMOCK 165/vector; uORF LTR; SIN; EFS SIN; and P(-) SIN 110/vector.
  • 14 months (Intravenous)  (C10844)  Histopath in progress 
    • Mice: C57BL/6
    • Dose: Female mice: 55/vector.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.