National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11048

Testing Status of BDE Toxicogenomics Study (TGMX) - 11048

 

CASRN: TGMXBDECLASS

Related: 68631-49-2; 60348-60-9; 5436-43-1; 32534-81-9; BDEMIXTURE

Formula: N/A

Secondary:

  • BDEMIXTURE - BDE Mixture (47, 99, 153)
  • 68631-49-2 - 2,2',4,4',5,5'-Hexabromodiphenyl ether (PBDE 153)
  • 60348-60-9 - 2,2',4,4',5-Pentabromodiphenyl Ether
  • 32534-81-9 - Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)]
  • 5436-43-1 - 2,2',4,4'-Tetrabromodiphenyl Ether

Known Uses

NTP toxicogenomics study of BDE 47, BDE 99, BDE 153, DE 71, and a mixture of BDE 47, 99, and 153

Planned Carcinogenicity/Toxicity

  • 3 weeks (Gavage) Selected (C11048)  
    • Rats: Wistar Han; Mice: B6C3F1
  • GD 6 to PND 21 (gestation dams) (Gavage) Selected (C11048)  
    • Rats: Wistar Han
  • PND 1 to PND 4 (lactation dams) (Gavage) Selected (C11048)  
    • Rats: Wistar Han
  • PND 4 to PND 21 (female pups) (Gavage) Selected (C11048)  
    • Rats: Wistar Han
  • PND 4 to PND 21 (male pups) (Gavage) Selected (C11048)  
    • Rats: Wistar Han
  • 13 weeks (Gavage) Selected (C11048)  
    • Rats: Wistar Han; Mice: B6C3F1

Toxicogenomics

  • Selected (T11048)  
    NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.