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Testing Status of Trimethylsilyldiazomethane (TMSD) 11049

 

CASRN: 18107-18-1

Formula: N/A

Synonyms/Common Names

  • Diazomethyltrimethyl silane
  • Diazo((trimethylsilyl))methane

Known Uses

Reagent for organic synthesis. [Safe] substitute for hazardous diazomethane. is useful both as a reagent for introducing a C1 unit and as a C-N-N synthon for the preparation ofazoles.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 10 days (Inhalation)  (C11049)  Data in Review 
    • Toxicity studies of TMSD
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: 1 Day: male rats and mice (N = 16/ exp. group) exposed to hexane, air or 20 ppm TMSD; N = 8 necropsied day after exposure and N = 8 necropsied 9 days after exposure. 5 Day: male rats and mice (N = 16 exp. group) exposed to hexane, air, or 0.2, 1, 5, or 20 ppm TMDS; N = 8 necropsied day after final exposure, N = 8 necropsied 5 days after final exposure.