National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11054

Testing Status of Sulfolane - 11054

 

CASRN: 126-33-0

Formula: C4-H8-O2-S

Synonyms/Common Names

  • Sulphoxaline

Known Uses

Selective solvent for liquid-vapor extractions. Solvent for aromatics extraction; for acid gas purification. Extraction of aromatic hydrocarbons from oil refinery streams; polymerization solvent; plasticizer. Fractionation of wood tars, tall oil, and other fatty acids; component of hydraulic fluid; textile finishing.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 28 days (Gavage)  (C11054)  Tox Review or Completed 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N; Guinea Pigs: Hartley
    • Dose: R, M, GP: 0, 1, 10, 30, 100, 300, or 800 mg/kg 10/sex/species/dose; 20/sex in control group for GP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C11054B)  On Test 
    • Chronic study of sulfolane
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: R&M: 0, 30, 100, 300, or 1000 ppm in tap water; 50/sex/species/group.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (K11054)  Report Complete 
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
  • Preliminary Toxicokinetic Study (Gavage; Intravenous)  (K11054B)  Report in Review 
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
  • Preliminary Toxicokinetic Study (Gavage; Intravenous)  (K11054C)  Report in Review 
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
  • Toxicokinetic Study (Gavage; Intravenous)  (K11054C)  Report in Review 
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N; Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N

Genetic Toxicology

  • Micronucleus  (G11054B)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G11054)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus (Dosed-Water)  (G11054C)  On Test 
    • Male
    • Rats: Harlan Sprague-Dawley
  • Micronucleus (Dosed-Water)  (G11054D)  On Test 
    • Female
    • Mice: B6C3F1

Organ Systems Toxicity

  • 13 weeks Immunotoxicity (Gavage)  (I11054B)  Report in Preparation 
    • Male and Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 30, 100, 300, or 1000 mg/L.
  • 13 weeks Immunotoxicity (Gavage)  (I11054)  Report in Preparation 
    • Female Mice: B6C3F1/N
    • Dose: 0, 1, 10, 30, 100, or 300 mg/kg.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.