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Testing Status of 1-Chloro-2-propanol 11078-G

 

CASRN: 127-00-4

Formula: C3-H7-Cl-O

Synonyms/Common Names

  • 1-Chloro-2-hydroxypropane

Known Uses

Intermediate in production of propylene oxide and other organic compounds. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination (Inhalation)  (S0215)  Completed 
    • Citation: Bond JA, Birnbaum LS, Dahl AR, Medinsky MA, Sabourin PJ, Henderson RF. Disposition of inhaled 1-chloro-2-propanol in F344/N rats. Toxicol Appl Pharmacol. 1988 Sep 30;95(3):444-55.Pubmed Abstract
    • Male Rats: F344/N
  • Absorption Disposition Metabolism Elimination  (S0791)  Completed 
    • Toxicokinetic Study (Gavage)  (S0539)  Completed 
      • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
      • Dose: MICE: 4.5, 22.5, AND 45 MG/KG RATS: 1.5, 7.5, AND 15 MG/KG.

    Genetic Toxicology

    • In Vitro Cytogenetics (CA/SCE)  (794630)  Completed 
      • Sister Chromatid Exchange Positive 
      • Chromosome Aberrations Positive 
    • Drosophila  (087443)  Completed 
      • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
      • Sex-Linked Recessive Lethal Positive 
      • Reciprocal Translocation Negative 
    • Salmonella  (111503)  Completed 
      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
      •  Positive 
    • Salmonella  (154127)  Completed 
      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
      •  Positive 
    • Salmonella  (648348)  Completed 
      • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
      •  Positive 

    Organ Systems Toxicity

    • greater than 120 days Continuous Breeding (Legacy) (Dosed-Water)  (RACB88075)  Completed 
      • Citation: Final Report on the Reproductive Toxicity of 1-Chloro-2-propanol in Sprague-Dawley Rats
      • Male and Female Rats: Sprague Dawley
      • Dose: 0, .1, .2, .4, .6, .8%; 0, .03, .065, .13%; ; 0, .13%.