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Testing Status of 2,3-Dichloropropylene 11080-H

 

CASRN: 78-88-6

Formula: C3-H4-Cl2

Synonyms/Common Names

  • 1-Propene, 2,3-dichloro-

Known Uses

Chemical intermediate.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C61881)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R & M: 0, 15.6, 31.2, 62.5, 125, 250 PPM (5/S/S).
  • 13 weeks (Inhalation)  (C61881)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 5.0, 10.0, 20.0, 40.0, OR 80.0 PPM (10/S/S).

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intraperitoneal Injection)  (S0702)  Completed 
    • Citation: Medinsky MA, Bond JA, Dutcher JS, Birnbaum LS. Disposition of [14C]2,3-dichloropropene in Fischer-344 rats after oral or intraperitoneal administration. Toxicol Lett. 1984 Oct;23(1):119-25.Pubmed Abstract
    • Male Rats: F344/N
  • Absorption Disposition Metabolism Elimination  (S0703)  Completed 
    • Citation: Dutcher JS, Medinsky MA, Bond JA, Cheng YS, Snipes MB, Henderson RF, Birnbaum LS. Effect of vapor concentration on the disposition of inhaled 2,3-dichloropropene in Fischer-344 rats. Fundam Appl Toxicol. 1985 Oct;5(5):997-1005.Pubmed Abstract
    • Rats: F344/N

Genetic Toxicology

  • Chromosome Aberrations  (313269)  Completed 
    • Mice
    •  Negative (Nonstandard Protocol) 
  • In Vitro Cytogenetics (CA/SCE)  (850916)  Completed 
    • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (964969)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Positive 
  • Sister Chromatid Exchanges  (313269)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol)