National Toxicology Program

National Toxicology Program

Testing Status of Methylene bis(thiocyanate) - 11082-R


CASRN: 6317-18-6

Formula: C3-H2-N2-S2

Synonyms/Common Names

  • Methylene dithiocyanate

Known Uses

Antifouling agent. Fungicide used in water-cooling towers (ACS 1990)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C61916)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Gavage)  (C61916)  Report Complete 
    • TOX-32 (NIH Number: 94-3381)  (Tox Peer Review 07/13/1993A )
      Toxicity Studies of Methylene bis(thiocyanate), (CASRN 6317-18-6) Administered by Gavage to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 1, 2, 4, 8, 16 MG/KG; GAVAGE IN METHYLCELLULOSE 10 ANIMALS/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0176)  Completed 
    • Citation: Chemical Disposition in Mammals: Final Report (Estimation of Cyanide as a Metabolite of Methylene Dithocyanate Ch2(Scn)2 in Blood of Male Fischer 344 Rats).
    • Male Rats: F344/N
    • Dose: 0.2, 1, 10 MG/KG.

Genetic Toxicology

  • Micronucleus  (A08030)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (818295)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.