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Testing Status of Mono(2-ethylhexyl)phthalate 11085-D

 

CASRN: 4376-20-9

Formula: C16-H22-O4

Synonyms/Common Names

  • 1,2-Benzenedicarboxylic acid, mono(2-ethylhexyl)ester (9CI)

Known Uses

Plasticizer. Laboratory reagent. Chemical intermediate. Synthetic perfumes and dyes.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (289374)  Completed 
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Negative 
  • In Vitro Cytogenetics (CA/SCE)  (898004)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (173389)  Completed 
    • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (262656)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (204559)  Completed 
    • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
    •  Negative 

Organ Systems Toxicity

  • 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0129A)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 545 MG/KG BODY WEIGHT.
  • 1 to 17 GD Conventional Teratology (Dosed-Feed)  (TER90002)  Completed 
    • Citation: Final Report on the Developmental Toxicity of Mono (2-Ethylhexyl) phthalate in CD-1 Swiss Mice
    • Female Mice: Swiss CD-1
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 0, 0.017, 0.035, 0.07, 0.14%.