Testing Status of Carbon tetrachloride 11112-R

 

CASRN: 56-23-5

Formula: C-Cl4

Synonyms/Common Names

  • Benzinoform
  • Freon 10
  • Halon 1040
  • Tetrachloromethane

Known Uses

Therapeutic nutrient. In linseed & soybean oils. Naturally occurring in food; in refrigerants; metal degreasing; production of semiconductors. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C03452A)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0, 2.5, 5.0, 7.5, 10. M: 0, 25 % 50/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Dosed-Water; Intraperitoneal Injection)  (S0060)  Completed 
    • Citation: Ghanayem BI, Burka LT. Comparative metabolism and disposition of 1-chloro-and 3-chloro-2-methylpropene in rats and mice. Drug Metabol Dispos. 1987 Jan-Feb;15(1):91-6.Pubmed Abstract
    • Male Rats: F344/N
  • Cell Proliferation (Gavage)  (S0229)  Completed 
    • Citation: Cunningham ML, Matthews HB. Relationship of hepatocarcinogenicity and hepatocellular proliferation induced by mutagenic noncarcinogens vs carcinogens. II. 1- vs 2-nitropropane. Toxicol Appl Pharmacol. 1991 Sep 15;110(3):505-13.Pubmed Abstract
    • Rats: F344/N
    • Dose: 0.4 ML/KG.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (398542)  Completed 
    • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (651566)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (082325)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 
  • Salmonella  (992990)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 

Organ Systems Toxicity

  • 7 days Immunotoxicity (Gavage)  (IMM92021)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 100, 500, 1000 MG/KG.
  • 14 days Immunotoxicity (Gavage)  (IMM94001)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 50, 100, 500 MG/KG.