National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11115-d

Testing Status of Methyl methanesulfonate - 11115-D

 

CASRN: 66-27-3

Formula: C2-H6-O3-S

Synonyms/Common Names

  • Methanesulfonic acid, methyl ester (9CI)

Known Uses

Research chemical: as chemosterilant and contraceptive

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • C. elegans  (S0879)  Completed 
    • C. elegans
    • Dose: feed (0, .2, .25, .32, .40, .5, .63, .79, 1, 1.3, 1.6, 2.0) mM 1/26/06 repro (0, .1, .13, .16, .2, .25, .32, .4, .5, .63, .79, 1) 5/20/05 growth (0, .02, .032, .05, .079, .13, .2, .32, .5, .79, 1.3, 2)mM 01/25/07.

Genetic Toxicology

  • Salmonella  (926355)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
  • Salmonella  (N-9144)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251

Organ Systems Toxicity

  • Dominant Lethal (Female)  (DLF026)  Completed 
    • Citation: Generoso, W.M., Shourbaji, A.G., Piegorsch, W.W., and Bishop, J.B. Developmental response of zygotes exposed to similar mutagens. Mutation Res. 250:439-446 (1991).
    • Female Mice: C3H X C57BL
    • Mice Female Negative 
  • Preimplantation Zygote Effects  (PZEF51)  Completed 
    • Citation: Generoso, W.M., Shourbaji, A.G., Piegorsch, W.W., and Bishop, J.B. Developmental response of zygotes exposed to similar mutagens. Mutation Res. 250:439-446 (1991).
    • Female Mice: C3H X C57BL
    • Mice Female Positive 
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