National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11128-x

Testing Status of Acrylonitrile - 11128-X

 

CASRN: 107-13-1

Formula: C3-H3-N

Synonyms/Common Names

  • AN
  • 2-Propenenitrile

Known Uses

Chem. Intermediate for antioxidants, pharmaceuticals, dyes, surface-active agents. Monomer in organic synthesis. Pesticide fumigant for grain. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Gavage)  (C50215B)  Completed 
    • Mice: B6C3F1
    • Dose: MICE: 0, 5, 10, 20, 40, OR 60 MG/KG; 10/SEX/DOSE.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C50215B)  Report Complete 
    • TR-506 (NIH Number: 02-4440)  (Peer Review Approval 05/03/2001A )
      Toxicology and Carcinogenesis Studies of Acrylonitrile (CASRN 107-13-1) in B6C3F1 Mice (Gavage Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: MICE: 0, 2.5, 10, OR 20 MG/KG; 50/SEX/DOSE.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0712)  Completed 
    • Citation: Burka LT, Sanchez IM, Ahmed AE, Ghanayem BI. Comparative metabolism and disposition of acrylonitrile and methacrylonitrile in rats. Arch Toxicol. 1994;68(10):611-8.Pubmed Abstract
    • Male Rats: F344/N
  • Other (Gavage)  (S0711)  Completed 
    • Citation: Farooqui MY, Mumtaz MM, Ghanayem BI, Ahmed AE. Hemoglobin degradation, lipid peroxidation, and inhibition of Na /K( )-ATPase in rat erythrocytes exposed to acrylonitrile. J Biochem Toxicol. 1990 Winter;5(4):221-7.Pubmed Abstract
    • Male Rats: Sprague Dawley

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (269328)  Completed 
    • Citation: Gulati, D., Sabharwal, P., and Shelby, M. Tests for the induction of chromosomal aberrations and sister chromatid exchanges in cultured Chinese hamster ovary (CHO) cells. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland 413-426
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Drosophila  (701238)  Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
    • Sex-Linked Recessive Lethal Negative 
    • Reciprocal Translocation Negative 
  • Mouse Lymphoma  (189387)  Completed 
    • Citation: Myhr, B., Bower, L., and Caspary, W. Assays for the induction of gene mutations at the thymine kinase locus in L1578Y mouse lymphoma cells in culture. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland Vol. (1985) 555-568
    • Mice
    •  Positive 
  • Micronucleus  (A56933)  Completed 
    • Mice: B6C3F1
    • Female Negative 
  • Micronucleus  (A69991)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A92525)  Completed 
    • Mice: B6C3F1
    • Female Negative 
  • Salmonella  (198018)  Completed 
    • Citation: Zeiger, E., and Haworth, S. Tests with a preincubation modification of the Salmonella/microsome assay. In Evaluation of Short-Term Tests for Carcinogens Elsevier/North Holland 187-199
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.