National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11132-g

Testing Status of m-Chloroaniline - 11132-G

 

CASRN: 108-42-9

Related: O-CHLOROANILINE (CAS 95-51-2) & P-CHLOROANILINE (CAS 106-47-8)

Formula: C6-H6-Cl-N

Synonyms/Common Names

  • 3-Chloroaniline
  • 3-Chlorobenzenamine

Known Uses

Intermediate for azo dyes and pigments. Pharmaceuticals. Insecticides.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Gavage)  (C61529B)  Report Complete 
    • TOX-43 (NIH Number: 98-3943)  (Tox Peer Review 09/15/1997A )
      Comparative Toxicity Studies of o-,m-, and p-Chloroanilines (CASRNs 95-51-2; 108-42-9; and 106-47-8) Administered by Gavage to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M 0, 10, 20, 40, 80, 160 MG/KG, 20/GRP (RATS); 10/GRP (MICE).

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (943184)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Mouse Lymphoma  (435631)  Completed 
    • Mice
    •  Positive 
  • Micronucleus  (A15534)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Micronucleus  (A81432)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A93812)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (309708)  Completed 
    •  Negative 
  • Salmonella  (356768)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
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