National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11137-c

Testing Status of Diethylene glycol monoethyl ether - 11137-C

 

CASRN: 111-90-0

Formula: C6-H14-O3

Synonyms/Common Names

  • 2-(2-Ethoxyethoxy)ethanol

Known Uses

Solvent in lacquer, varnishes, enamels, and cosmetics.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Salmonella  (851593)  Completed 
    •  Negative 

Organ Systems Toxicity

  • continuous exposure, 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB83088)  Completed 
    • Citation: Final Report - Diethylene Glycol Monoethyl Ether: Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Drinking Water
    • Male and Female Mice: Swiss
    • Dose: 0,1,2,3,4,5%; 0,.25,1.25,2.5%; N/A; 0,2.5%.
  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0078A)  Completed 
    • Citation: Screening of Priority Chemicals for Reproductive Hazards
    • Female Mice: Swiss
    • Dose: 5500 MG/KG BD WT.
  • 7 to 16 GD (vaginal sperm = 1 GD) Conventional Teratology (Topical Application)  (T0078B)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0.35 ml undiluted, 4 times/day.
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