National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11140-g

Testing Status of Diethylene glycol diethyl ether - 11140-G

 

CASRN: 112-36-7

Formula: C8-H18-O3

Synonyms/Common Names

  • Ethane, 1,1'-oxybis(2-ethoxy-

Known Uses

High boiling reaction medium, solvent for nitrocellulose, lacquers, solvent for adhesives, sealants, plastic compounds, rubber chems; coupling agents for miscible organic-aqueous systems.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Salmonella  (718191)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0082A)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 3000 MG/KG BD WT.
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER86059)  Completed 
    • Citation: Teratologic Evaluation of Diethylene Glycol Diethyl Ether Administered to CD-1 Mice on Gestational Days 6-15
    • Female Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 0, 300, 1500, 3000, 4500 MG/KG/DAY.
  • 6 to 19 GD Conventional Teratology (Gavage)  (TER87060)  Completed 
    • Citation: Teratologic Evaluation of Diethylene Glycol Diethyl Ether Administered to New Zealand White Rabbits...
    • Female Rabbit: New Zealand White
    • Rabbits Maternal Inadequate 
    • Rabbits Fetal Negative 
    • Dose: 0, 50, 200, 400 MG/KG.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.