National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11141-k

Testing Status of Triethylene glycol dimethyl ether - 11141-K

 

CASRN: 112-49-2

Formula: C8-H18-O4

Synonyms/Common Names

  • 2,5,8,11-Tetraoxadecane (9CI)

Known Uses

Pesticide

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (439492)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Salmonella  (344240)  Completed 
    •  Positive 

Organ Systems Toxicity

  • continuous exposure, 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB83117)  Completed 
    • Citation: Final Report - Triethylene Glycol Dimethyl Ether: Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Drinking Water
    • Male and Female Mice: Swiss
    • Dose: 0, 0.25, 0.5, 1.0, 2.5, 5.0%; 0, .25, .5, 1.0%; 0, 1.0%; N/A.
  • 8 consecutive days (MTD PHASE), 7 to 14 GD (reproductive phase) Short-Term in vivo Repro. Tox. (Gavage)  (T0083A)  Completed 
    • Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
    • Female Mice: Swiss
    • Dose: 3500 MG/KG BODY WEIGHT.
  • GD 11 (plug =gGD 0) Conventional Teratology (Gavage)  (T0083E)  Completed 
    • Female Mice: Swiss
    • Dose: 713 mg/kg (4.0 mmol/kg).
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER84112)  Completed 
    • Citation: Teratologic Evaluation of Triethylene Glycol Dimethyl Ether Administered to CD-1 Mice on Gestational Days 6 through 15
    • Female Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 0, 250, 500, 1000 MG/KG/DAY.
  • 6 to 19 GD Conventional Teratology (Gavage)  (TER85113)  Completed 
    • Citation: Teratologic Evaluation of Triethylene Glycol Dimethyl Ether Administered to New Zealand White Rabbits...
    • Female Rabbit: New Zealand White
    • Rabbits Maternal Positive 
    • Rabbits Fetal Positive 
    • Dose: 0, 75, 125, 175, 250 MG/KG/DAY.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.