National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11144-x

Testing Status of Tetrafluoroethylene - 11144-X

 

CASRN: 116-14-3

Formula: C2-F4

Synonyms/Common Names

  • Ethene, Tetrafluoro- (9Ci)

Known Uses

Monomer for polytetrafluoroethylene polymers. Preparation of propellants for food product aerosols. Chemical intermediate.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Inhalation)  (C61596)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Inhalation)  (C61596)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 312, 625, 1250, 2500, 5000 PPM/010 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C61596B)  Report Complete 
    • TR-450 (NIH Number: 97-3366)  (Peer Review Approval 12/05/1995A )
      Toxicology and Carcinogenesis Studies of Tetrafluoroethylene (CASRN 116-14-3) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: MICE & FR: 0, 312, 625, OR 1250 MR: 0, 156, 312, OR 625 PPM; 50/GROUP.

Genetic Toxicology

  • Micronucleus  (A09684)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
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