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Testing Status of tris(2-Chloroethyl) phosphite 11148-N

 

CASRN: 140-08-9

Formula: C6-H12-Cl3-O3-P

Synonyms/Common Names

  • 2-Chloroethanol phosphite (3:1) (9CI)

Known Uses

Intermediate; component of vinyl stabilizers, grease additives, fire retardant; color inhibitor for esters.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination (Intravenous)  (S0211)  Completed 
    • Citation: Dix K, Deterding LJ, Burka LT, Tomer KB. Tris(2-chloroethyl) phosphate pharmacokinetics in the Fischer 344 rat: a comparison of conventional methods and in vivo microdialysis coupled with tandem mass spectrometry. J Pharm Sci. 1994 Nov;83(11):1622-9.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 20 MG/KG.

Genetic Toxicology

  • Drosophila  (538966)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
  • Salmonella  (546373)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Weakly Positive 
  • Salmonella  (881124)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Equivocal