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Testing Status of Oxymetholone 11167-A

 

CASRN: 434-07-1

Formula: C21-H32-O3

Synonyms/Common Names

  • 5Alpha-Androstan-3-One,17Beta-Hydroxy-2-(Hydroxymethylene)- 17-Methyl- (8Ci)
  • (5alpha,17beta)-17-hydroxy-2-(hydroxymethylene)-17-methyl-androstan-3-one (9CI)
  • Anadrol
  • Anasteronal
  • Nastenon
  • Oximetholone
  • Pavisoid

Known Uses

Maintain a positive nitrogen balance. To promote weight gain in cachexia, debilitating diseases, serious infections, burns, trauma and surgery. Treatment of anemias. (NTP executive summary)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C88032B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 160, 315, 625, 1250, OR 2500 MG/KG; 5/SEX/GROUP M: 0, 320, 630, 1250, 2500, OR 5000 MG/KG; 5/SEX/GROUP.
  • 2 weeks (Dosed-Feed)  (C88032)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.34, 0.67, 1.25, 2.50, OR 5% (5/SEX/SPECIES/GROUP).
  • 13 weeks (Gavage)  (C88032B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 80, 160, 315, 625, OR 1250 MG/KG; 20/SEX/GROUP M: 0, 160, 320, 630, 1250, OR 2500 MG/KG; 10/SEX/GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C88032B)  Completed 
    • TR-485 (NIH Number: 99-2975)  (Peer Review Approval 10/30/1998A )
      Toxicology and Carcinogenesis Studies of Oxymetholone (CASRN 434-07-1) in F344/N Rats and Toxicology Studies of Oxymetholone in B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats Clear Evidence 
    • Dose: MR: 0, 3, 30, OR 150 MG/KG; FR: 0, 3, 30, OR 100 MG/KG.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0193)  Completed 
    • Male Rats: F344/N
    • Dose: 5, 50 mg/kg.
  • Toxicokinetic Study (Gavage; Intravenous)  (S0569)  Completed 
    • Male and Female Rats: F344/N; Male Mice: B6C3F1; Male Rats: F344/N; Male Mice: B6C3F1
    • Dose: (UNITS MG/KG BW): RATS: gav: males: 3, 30, 150; females: 3, 30, 100 mouse chronic cancelled..

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (A62570)  Completed 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A29765)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (990860)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 

Organ Systems Toxicity

  • 14 days Immunotoxicity (Gavage)  (IMM90012)  Completed 
    • Citation: NTP Report on the Immunotoxicity of Oxymetholone (CASRN: 434-07-1) in male B6C3F1 Mice (immune modulation studies)
    • Female Mice: B6C3F1
    • Mice Female Negative 
    • Dose: 0, 50, 150, 300 MG/KG.