National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11171-j

Testing Status of Melphalan - 11171-J

 

CASRN: 148-82-3

Related: TRANSGENIC MODEL EVALUATION (MELPHALAN)

Formula: C13-H18-Cl2-N2-O2

Synonyms/Common Names

  • 4-(Bis(2-chloroethyl)amino)-DL-phenylalanine

Known Uses

Chemotherapeutic used to treat multiple myeloma, cancer of the ovary

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C04853)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss
  • 13-Week (Intraperitoneal Injection)  (C04853)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C04853)  Report Complete 
    •   (Peer Review Approval NA) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
    • Rats: Sprague Dawley; Mice: Swiss
    • Dose: R: 0, .7, 1.4, M: 0, .35, .70 MG/KG/25 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (141321)  Completed 
    • Citation: Shelby, M.D., Gulati, D.K., Tice, R.R., and Wojciechowski, J.P. Results of tests for micronuclei and chromosomal aberrations in mouse bone marrow cells with the human carcinogens 4-aminobiphenyl, treosulphan, and melphalan. Environ. Molec. Mutagen. Vol. 13 (1989) 339-342
    • Mice
    •  Positive (Nonstandard Protocol) 
  • In Vitro Cytogenetics (CA/SCE)  (283792)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (141321)  Completed 
    • Citation: Shelby, M.D., Gulati, D.K., Tice, R.R., and Wojciechowski, J.P. Results of tests for micronuclei and chromosomal aberrations in mouse bone marrow cells with the human carcinogens 4-aminobiphenyl, treosulphan, and melphalan. Environ. Molec. Mutagen. Vol. 13 (1989) 339-342
    • Mice: B6C3F1
    • Male Positive 
  • Micronucleus  (A19873)  Completed 
    • Mice: Tg.AC (FVB/N) Homozygous
    • Male Weakly Positive 
    • Female Positive 
  • Micronucleus  (A52832)  Completed 
    • Mice: Tg.AC (FVB/N) Homozygous
    • Male Positive 
    • Female Positive 
  • Micronucleus  (A84411)  Completed 
    • Mice: FVB/N
    • Male Positive 
    • Female Positive 
  • Micronucleus  (A93719)  Completed 
    • Mice: FVB/N
    • Male Positive 
    • Female Positive 
  • Salmonella  (331518)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 
  • Sister Chromatid Exchanges  (141321)  Completed 
    • Citation: Shelby, M.D., Gulati, D.K., Tice, R.R., and Wojciechowski, J.P. Results of tests for micronuclei and chromosomal aberrations in mouse bone marrow cells with the human carcinogens 4-aminobiphenyl, treosulphan, and melphalan. Environ. Molec. Mutagen. Vol. 13 (1989) 339-342
    • Mice
    • Sister Chromatid  Positive (Nonstandard Protocol) 

Organ Systems Toxicity

  • Dominant Lethal (Male)  (DLM96003)  Completed 
    • Citation: Generoso, WM, Witt, KL, Cain, KT, Hughes, L, Cacheiro, NLA, Lockhart, A-MC, Shelby, MD. Dominant lethal and heritable translocation tests with chlorambucil and melphalan in male mice. Mutat. Res. 345: 167-180. (1995)
    • Male Mice: C3H X 101
    • Mice Male Positive 
  • Heritable Translocation Test  (HTT96002)  Completed 
    • Citation: Generoso, WM, Witt, KL, Cain, KT, Hughes, L, Cacheiro, NLA, Lockhart, A-MC, Shelby, MD. Dominant lethal and heritable translocation tests with chlorambucil and melphalan in male mice. Mutat. Res. 345: 167-180. (1995)
    • Male Mice: C3H X 101
    • Mice Male Positive 
  • Morphological Specific Locus  (MSLM67)  Completed 
    • Citation: Russell, L.B., Hunsicker, P.R., and Shelby, M.D. Melphalan, a second chemical for which specific-locus mutation induction in the mouse is maximum in early spermatids. Mutation Res. 282: 151-158 (1992).
    • Male Mice: 101 X C3H
    • Mice Male Positive 
  • Total Reproductive Capacity  (TRC98021)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice
    • Mice Female Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.