National Toxicology Program

National Toxicology Program

Testing Status of bis(Chloromethyl) ether - 11173-S


CASRN: 542-88-1

Formula: C2-H4-Cl2-O

Synonyms/Common Names

  • Oxybis(chloromethane)

Known Uses

Production of anion exchange resins, plastics, potential use in dental restorative materials. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Long-Term Carcinogenicity

  • lifetime (Inhalation)  (C06940)  Completed 
    • Rats: Sprague Dawley; Hamsters: Syrian Golden
    • Dose: R: 0,.1,1,2.1,3.7,6.9,9.5 PPM H: 0,.1,.7,1,2.1,5.6,9.9 PPM /25-50 ANIMALS PER GROUP.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.