National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11179-r

Testing Status of tert-Butyl perbenzoate - 11179-R

 

CASRN: 614-45-9

Formula: C11-H14-O3

Synonyms/Common Names

  • Benzenecarboperoxoic acid, 1,1-dimethylethyl ester

Known Uses

Curing agent for unsaturated polyesters. Polymerization initiator for polyester and other resins. Chemical intermediate.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C61518)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: TOXICITY.
  • 13 weeks (Gavage)  (C61518)  Report Complete 
    • TOX-15 (NIH Number: 92-3134)
      Toxicity Studies of t-Butyl Perbenzoate (CASRN 614-45-9) Administered by Gavage to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,30,60,125,250,500 MG/KG.

Special Studies

  • Absorption Disposition Metabolism Elimination (Intravenous; Topical Application)  (S0053)  Completed 
    • Male Rats

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (096324)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (A96924)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (923771)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.