Testing Status of N-Nitroso-N-methylurea 11184-E

 

CASRN: 684-93-5

Formula: C2-H5-N3-O2

Synonyms/Common Names

  • 1-Methyl-1-nitrosourea

Known Uses

Antineoplastic agent, chemical intermediate, mutagen to various plants. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Micronucleus  (A35550)  Completed 
    • Mice: B6C3F1
    • Male Positive 

Organ Systems Toxicity

  • Dominant Lethal (Male)  (DLM027)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Cornett, C.C., and Cacheiro, N.L.A. DNA target sites associated with chemical induction of dominant-lethal mutations and heritable translocations in mice. In: Genetics: New Frontiers. Proceedings of the XV International Congress of Genetics, Oxford and IBH Publishing Co. New Delhi, 1983, pp. 347-355.
    • Male Mice: 101 X C3H
    • Mice Male Positive 
  • Heritable Translocation Test  (HTM34)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Cornett, C.C., and Cacheiro, N.L.A. DNA target sites associated with chemical induction of dominant-lethal mutations and heritable translocations in mice. In: Genetics: New Frontiers. Proceedings of the XV International Congress of Genetics, Oxford and IBH Publishing Co. New Delhi, 1983, pp. 347-355.
    • Male Mice: 101 X C3H
    • Mice Male Positive 
  • Morphological Specific Locus  (MSLM45)  Completed 
    • Citation: Russell, W.L. and Hunsicker, P.R. Extreme sensitivity of one particular germ cell stage in male mice to induction of specific-locus mutations by methylnitrosourea. Environ. Mutagen. 5:498 (1983)
    • Male Mice: 101 X C3H
    • Mice Male Positive 
  • Total Reproductive Capacity (Intraperitoneal Injection)  (TRC98024)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice
    • Mice Female Positive 
  • PYRAN 3 GD, MNU 9 GD Teratology Pilot Studies (Gavage & Intraperitoneal Injection)  (TRP92060)  Completed 
    • Male and Female Mice: Swiss & C57BL/6
    • Dose: 10 MG/KG MNU (GD 9) + 10 MG/KG PYRAN.