National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11185-h

Testing Status of N-Ethyl-N-nitrosourea - 11185-H

 

CASRN: 759-73-9

Formula: C3-H7-N3-O2

Synonyms/Common Names

  • 1-Ethyl-1-nitrosourea

Known Uses

Research chemicals used for lab preparation of diazobenzene, has been used for promoting plant growth. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • C. elegans  (S0951)  Completed 
    • C. elegans

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (226054)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (A38658)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (531464)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 

Organ Systems Toxicity

  • Biochemical Specific Locus (Gavage)  (BSLM39)  Completed 
    • Citation: Lewis, S., Barnett, L., and Shelby, M. ENU mutagenesis in the mouse electrophoretic specific-locus test 2. Mutational studies of mature oocytes. Mutation Res. 296: 129-134 (1992).
    • Male Mice: C57BL/6J (Jackson)
    • Mice Male Positive 
  • Biochemical Specific Locus (Gavage)  (BSLM40)  Completed 
    • Citation: Lewis, L., Barnett, L., Sadler, B., and Shelby, M. (1991) ENU mutagenesis in the mouse electrophoretic specific locus test 1. Dose-response relationship of electrophoretically-detected mutations arising from mouse spermatogonia treated with ENU. Mutation Res. 249: 311-316.
    • Male Mice: DBA/2J
    • Mice Male Positive 
  • Dominant Lethal (Male) (Gavage)  (DLM024)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Cornett, C.C., and Cacheiro, N.L.A. DNA target sites associated with chemical induction of dominant-lethal mutations and heritable translocations in mice. In: Genetics: New Frontiers. Proceedings of the XV International Congress of Genetics, Oxford and IBH Publishing Co. New Delhi, 1983, pp. 347-355.
    • Male Mice: 101 X C3H
    • Mice Male Positive 
  • Heritable Translocation Test (Dosed-Feed)  (HTM33)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Cornett, C.C., and Cacheiro, N.L.A. DNA target sites associated with chemical induction of dominant-lethal mutations and heritable translocations in mice. In: Genetics: New Frontiers. Proceedings of the XV International Congress of Genetics, Oxford and IBH Publishing Co. New Delhi, 1983, pp. 347-355.
    • Male Mice: 101 X C3H
    • Mice Male Positive 
  • Morphological Specific Locus (Dosed-Feed)  (MSLM43)  Completed 
    • Citation: Russell, L.B., Russell, W.L., Rinchik, E.M., and Hunsicker, P.R. Factors affecting the nature of induced mutations. In: Banbury Report 34: Biology of Mammalian Germ Cell Mutagenesis (J. Allen, B. Bridges, M. Lyon, M. Moses and L.B. Russell, Eds.). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1990, pp. 271-289.
    • Male Mice: 101 X C3H
    • Mice Male Positive 
  • Preimplantation Zygote Effects (Dosed-Water)  (PZEF52)  Completed 
    • Citation: Generoso, W.M., Rutledge, J.C., Cain, K.T., Hughes, L.A., and Downing, D.J. Mutagen-induced fetal anomalies and death following treatment of females within hours after mating. Mutation Res. 199: 175-181 (1988).
    • Citation: Rutledge, J.C., Generoso, W.M., Shourbaji, A., Cain, K.T., Gans, M., and Oliva, J. Developmental anomalies derived from exposure of zygotes and first-cleavage embryos to mutagens. Mutation Research 296: 167-177 (1992).
    • Female Mice: C3H X C57BL
    • Mice Female Positive 
  • Total Reproductive Capacity (Gavage)  (TRC98018)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice
    • Mice Female Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.