National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-11192-e

Testing Status of Gallium arsenide - 11192-E

 

CASRN: 1303-00-0

Formula: As-Ga

Synonyms/Common Names

  • Gallium monoarsenide

Known Uses

Semiconductors. Magnetoresistance devices. Light-emitting diodes. Microwave generation.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C62033)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R & M: 0, 1, 10, 37, 75 OR 150 MG/M3 (5/S/S).
  • 13 weeks (Inhalation)  (C62033)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M:0,0.1,1,10,37,75 MG/M3/20 & 10 PER GROUP RESPECTIVELY.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C62033B)  Report Complete 
    • TR-492 (NIH Number: 00-3951)  (Peer Review Approval 05/21/1999A )
      Toxicology and Carcinogenesis Studies of Gallium Arsenide (CASRN 1303-00-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Clear Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 0.01, 0.1, OR 1.0 MG/M3; 50/SEX/GROUP M: 0, 0.1, 0.5, OR 1.0 MG/M3; 50/SEX/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intratracheal)  (S0144)  Completed 
    • Citation: Carter DE, Bellamy WT. Toxicology of the group III-V intermetallic semiconductor, gallium arsenide. In: Clarkson TW, Frieberg L, Nordberg GF, and Sager PR, eds. Biological Monitoring of Toxic Metals. Plenum Publishing Corp. 1988:455-468.
    • Male Rats
    • Dose: PO:10,100,1000 INTRATRACHEAL:100 MG/KG.
  • Absorption Disposition Metabolism Elimination (Intratracheal)  (S0444)  Completed 
    • Citation: Webb DR, Wilson SE, Carter DE. Comparative pulmonary toxicity of gallium arsenide, gallium(III) oxide, or arsenic(III) oxide intratracheally instilled into rats. Toxicol Appl Pharmacol. 1986 Mar 15;82(3):405-16.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 100 mg/kg.
  • Absorption Disposition Metabolism Elimination (Gavage; Intratracheal)  (S0445)  Completed 
    • Citation: Webb DR, Sipes IG, Carter DE. In vitro solubility and in vivo toxicity of gallium arsenide. Toxicol Appl Pharmacol. 1984 Oct;76(1):96-104.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 10, 100, or 1000 mg/kg for gavage. 10, 30, or 100 mg/kg for Intratracheal.
  • Absorption Disposition Metabolism Elimination (Intratracheal)  (S0470)  Completed 
    • Citation: Rosner MH, Carter DE. Metabolism and excretion of gallium arsenide and arsenic oxides by hamsters following intratracheal instillation. Fundam Appl Toxicol. 1987 Nov;9(4):730-7.Pubmed Abstract
    • Male Hamsters: Syrian Golden
  • Absorption Disposition Metabolism Elimination (Gavage; Intratracheal)  (S0766)  Completed 
    • Rats
    • Dose: gavage, 10, 100 or 1000 mg/kg. intratracheal 10, 30, 0r 100 mg/kg.
  • Absorption Disposition Metabolism Elimination (Intratracheal)  (S0767)  Completed 
    • Citation: Webb DR, Wilson SE, Carter DE. Pulmonary clearance and toxicity of respirable gallium arsenide particulates intratracheally instilled into rats. Am Ind Hyg Assoc J. 1987 Jul;48(7):660-7.Pubmed Abstract
    • Male Rats: F344/N
  • Toxicokinetic Study (Inhalation)  (S0564)  Completed 
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
    • Dose: RAT: 0, 0.01, 0.1, & 1.0 MG/M3; MICE: 0, 0.1, 0.5, & 1.0 MG/M3.

Genetic Toxicology

  • Micronucleus  (A56833)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (006180)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 

Organ Systems Toxicity

  • Immunotoxicity (Intratracheal)  (IMM90013)  Completed 
    • Citation: NTP Summary Reports on Immunotoxicology Vol. 1, No. 1-15: Immunotoxicity of Gallium Arsenide in Female B6C3F1 Mice
    • Female Mice: B6C3F1
    • Mice Female Positive 
    • Dose: 0, 50, 100, 200 MG/KG.
  • 4 to 19 GD Conventional Teratology (Inhalation)  (TER89143)  Completed 
    • Citation: Inhalation Developmental Toxicology Studies: Gallium Arsenide in Mice and Rats (December 1990)
    • Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 0, 10, 37, 75 MG/CUBIC METER.
  • 4 to 17 GD Conventional Teratology (Inhalation)  (TER90043)  Completed 
    • Citation: Inhalation Developmental Toxicology Studies: Gallium Arsenide in Mice and Rats (December 1990)
    • Female Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 10, 37, 75 MG/CUBIC METER.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.